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Don Sphynxs are hairless so they don't need combing and don't shed, free from musk odor. They are inclined to sweat so need daily wiping with cloths as well as regular bathing. Due to high body temperature Sphynxs need more food than other breeds. The high body temperature also help Sphynxs to resist infections. Adult Sphynxs possess high immunity to most desease. But it is important to keep them away from draughty places.

While Sphynx cats lack a coat to shed or groom, they are not maintenance-free. Body oils, which would normally be absorbed by the hair, tend to build up on the skin. As a result, regular cleaning (usually in the form of bathing) is necessary; one bath a week is usually sufficient. Care should be taken to limit the Sphynx cat's exposure to outdoor sunlight at length, as they can develop sunburn and photo damage similar to that of humans. In general, Sphynx cats should never be allowed outdoors unattended, as they have limited means to conserve body heat when it is cold. Their curious nature can take them into dangerous places or situations.